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39-47_0408PP_aan het Rot_CME.indd

Conventional pharmacologic treatments for major depressive disorder (MDD) generally take several weeks to several months to have a clinically meaningful effect. This time lag to response constitutes a major burden for patients and contributes to increased morbidity and mortality. Two published studies in patients with MDD have now provided evidence for rapid and robust antidepressant efficacy o...

Applied stochastic Eigen-analysis

The first part of the dissertation investigates the application of the theory of large random matrices to high-dimensional inference problems when the samples are drawn from a multivariate normal distribution. A longstanding problem in sensor array processing is addressed by designing an estimator for the number of signals in white noise that dramatically outperforms that proposed by Wax and Ka...

Eigen Analysis of Networks

We present an overview of eigen analysis methods and their applications to network analysis. We consider several network analysis programs/procedures (Correspondence Analysis, NEGOPY, CONCOR, CONVAR, Bonacich centrality) that are at their core eigendecomposition methods. We discuss the various matrix representations of networks used by these procedures and we give particular attention to a vari...

Incremental Eigen Decomposition

Eigen decomposition is a central mathematical tool in many pattern recognition and machine learning techniques. However, it becomes computationally infeasible in the presence of a large set of high-dimensional samples. Moreover, in highly dynamic domains with a continual supply of new samples, an incremental approach that keeps on updating the eigen decomposition will be more desirable than the...

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